HPV in immunocompromised patients

Immunostaining for High-Risk Human Papillomavirus in

HPV vaccination of immunocompromised host

BACKGROUND AND DESIGN: Human papillomavirus (HPV) is accepted as a factor in the pathogenesis of genital squamous cell carcinomas. The incidences of both HPV infection and squamous cell carcinoma are increased in immunocompromised renal transplantation patients. The purpose of this study was to determine if HPV DN HPV types 16, 18, 31, 33, and 35 are also occasionally found in anogenital warts (usually as co-infections with HPV 6 or 11) and can be associated with foci of high-grade squamous intraepithelial lesions (HSIL), particularly in persons who have HIV infection A high prevalence of HPV DNA was similarly detected in squamous cell carcinomas from immunocompromised patients; the HPV types found were exclusively EV related. CONCLUSIONS: The use of a combined degenerate primer PCR approach considerably improves HPV DNA detection over individual primer sets and allows detection of mixed infections ICVT in HPV-induced Genital Lesions of Immunocompromised and Immunocompetent Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details

HPV vaccination of immunocompromised hosts - ScienceDirec

Severe Plantar Warts in an Immunocompromised Patient. List of authors. Gehaan F. D'Souza, M.D., and James E. Zins, M.D. July 20, 2017. N Engl J Med 2017; 377:267. DOI: 10.1056/NEJMicm1616238. A. CIN is common in patients with HIV because [ 4-8 ]: ● Human papillomavirus (HPV) infection, the leading pathogen of most cervical cancers, is endemic among sexually active individuals. ● Patients with HIV are more likely to have persistent HPV infection Yes, HPV is an STI, but the vast majority of cases of HPV go away all on their own about 90% of the time. I always tell my patients that HPV is a natural consequence of being sexually active HPV vaccines are administered as a two-dose series (0, 6-12 months) for most persons who initiate vaccination at ages 9 through 14 years, and a three-dose series (0, 1-2, 6 months) for persons who initiate at ages 15 through 45 years, and for immunocompromised persons. Vaccine Informatio Overview of HPV-Related Manifestations Most HPV infections are transient, asymptomatic, or subclinical, and, among immunocompetent individuals, most HPV infections have no clinical consequences. Patients with clinically evident disease have a range of possible presentations that correlate with the HPV type and host factors. [ 38

ACIP Altered Immunocompetence Guidelines for Immunizations

Evidence linking HPV to KCs is accumulating. 6-8 The presence of HPV in warts, actinic keratoses, and cutaneous SCCs in immunocompromised patients, especially immunocompromised patients after solid organ transplant, has been well documented. 2,9 Recently, studies have shown that HPV may be a risk factor for the development of SCCs in some. Two HPV types (16 and 18) cause 70% of cervical cancers and pre-cancerous cervical lesions. There is also evidence linking HPV with cancers of the anus, vulva, vagina, penis and oropharynx. Cervical cancer is the fourth most common cancer among women globally, with an estimated 570,000 new cases in 2018

Another group of patients who are prone to SCCs is immunosuppressed patients. The HPV virus has been shown to elicit an antibody and cell-mediated immune response, with the T-cell response, specifically, playing a major role against HPV immunity patients with a history of anal condylomas have a high risk of anal SCC, especially men. The prevalence of HR-HPV and HSIL in condylomas from immunocompromised patients is high. This information can change patient follow-up and treatment Executive Summary. Immunocompromised populations are at increased risk for HPV infection and for developing HPV-associated cancers. However, additional clarity is required surrounding the immunogenicity and safety outcomes of HPV immunization for immunocompromised populations Safety and efficacy in immunocompromised patients not established. If used for treatment of genital HPV warts in HIV-infected individuals†, consider that these patients may not respond as well and may have more frequent recurrences after treatment compared with immunocompetent individuals. Patients with Autoimmune Disorder Human papillomavirus (HPV)—a small, double-stranded DNA virus—is the most common sexually transmitted infection in the United States. 1 Approximately 20 million Americans between the ages of 15 and 49 years are currently infected, and an estimated 6.2 million new infections occur each year. 2 It is estimated that 50% of sexually active.

HPV Carcinomas in Immunocompromised Patients

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Patients with immunodeficiencies are at increased risk of developing persistent HPV infection and as such HPV-related disease (genital warts and cancer). In this study HIV-patients and SOT-patients will receive 3 doses of Gardasil®9 The HPV Vaccine Schedule Population # of doses Routine schedule Minimum intervals Started series at age 9 through 14 years, except immunocompromised persons 2 0, 6 to 12 months 5 months between doses Started series at age 15 through 26 years, and immunocompromised persons (any age) 3 0, 1 to 2, 6 months 4 weeks between doses 1-2 12 weeks. Two HPV types (16 and 18) cause 70% of cervical cancers and pre-cancerous cervical lesions. There is also evidence linking HPV with cancers of the anus, vulva, vagina, penis and oropharynx. Cervical cancer is the fourth most common cancer among women globally, with an estimated 570,000 new cases in 2018 (HPV DNA testing), with exception that colposcopy may be deferred until at least 6 weeks postpartum if indicated 14 Patients HPV negative can be followed with repeat pap test at 6 weeks postpartum 14 Recommend against use of HPV triage in patients < 20 years Risk of cancer is relatively low among pregnant women wit

Most cases of human papilloma virus (HPV) infection are asymptomatic, transient and resolve without treatment. However, in some individuals, especially those patients who are immunocompromised because of various underlying diseases and those who are receiving long-term immunosuppressive agents, HPV infection is persistent and may result in genital warts, cervical smear abnormalities, cervical. Primary HPV screening should not be performed in women younger than 25 years or older than 65 years, or in women who are immunocompromised.4 Rescreening after a negative primary HPV test result. Human papillomavirus (HPV) is a very common virus that causes genital, oral, and skin infections. It is spread easily through intimate skin-to-skin contact. People of all genders can get HPV, and spread it to others without realizing they have the virus. HPV infection is most commonly acquired in the late teens and early 20s If the person needs HPV vaccine, 9vHPV (9-valent HPV) vaccine is recommended in a 3-dose schedule (0, 2, 6 months). This is regardless of the person's age at the start of vaccination (see Human papillomavirus). Influenza vaccine. All cancer patients aged ≥6 months are recommended to receive influenza vaccine each year

HPV infection and vaccination in Systemic Lupus

  1. ent transplantation in a 7- or 8-year-old child, recognizing that there is no immunogenicity data for this age group
  2. ate abnormal cells. And in patients with blood cancers such as leukemia, lymphoma or multiple myeloma, the immune system may not function.
  3. e the immunogenicity, safety and persistence of immunity following human papillomavirus (HPV) vaccination in three groups of immunosuppressed children: recipients of allogenic bone marrow transplant, recipients of renal and liver transplants, and patients with juvenile chronic arthritis, inflammatory bowel disease and other autoimmune conditions who are on longterm immunosuppressive.

HPV Vaccine Recommendations CD

Anal intraepithelial neoplasia: diagnosis, screening, and

The risk of an immunosuppressed patient developing squamous cell carcinoma (SCC) is 64 to 250 times higher than for an immunocompetent patient, and SCC in immunocompromised patients is more likely to be HPV-related [6, 7] US Pharm. 2010;35(9):32-40. Human papillomavirus (HPV)—a small, double-stranded DNA virus—is the most common sexually transmitted infection in the United States. 1 Approximately 20 million Americans between the ages of 15 and 49 years are currently infected, and an estimated 6.2 million new infections occur each year. 2 It is estimated that 50% of sexually active males will acquire a. In the United States, approximately 80% of HPV-related cancers are attributable to HPV 16 or 18 which are included in all three HPV vaccines that have been available in the U.S. Approximately 12% are attributable to HPV types 31, 33, 45, 52, and 58 (16% of all HPV-attributable cancers for females; 6% for males; approximately 3,800 cases. 2. The American Academy of Pediatrics (AAP) in February, 2017 recommended a 2-dose HPV vaccine series for non-immunocompromised children who begin the series before 15 years of age. 3. Bivalent HPV vaccine (2vHPV*, CervarixTM) and quadrivalent HPV vaccine (4vHPV**, Gardasil®) are currently not available in the United States HPV is transmitted sexually in most cases but can also be transmitted prenatally, by auto-inoculation or hetero-inoculation from non-genital warts. Anogenital warts have a 60% transmission rate between partners. Over 95% of genital warts are caused by infection with HPV types 6 and 11

Shingrix is recommended to prevent shingles and its complications in adults 50 and older. You and patients should make every effort to ensure that two doses are administered within the recommended 2-6 month interval. If more than 6 months have elapsed since the first dose, administer the second dose as soon as possible Management of Genital Warts. CHARLES M. KODNER, M.D., and SORAYA NASRATY, M.D., University of Louisville School of Medicine, Louisville, Kentucky. Am Fam Physician. 2004 Dec 15;70 (12):2335-2342. HPV serotyping was performed on all patient samples. We compared incidence of high-risk HPV and dysplasia in condyloma specimens from IC and NIC patients. Results High-risk HPV was identified in 14 specimens with serotypes 16, 18, 31, 33, 51, 52, and 67. Twenty-two cases (18.3%) had dysplasia. Invasive carcinoma was identified in one IC patient

Cervical Precancerous Dysplasia Facts. Cervical dysplasia, also known as high grade squamous intraepithelial lesion (HSIL), a precancerous condition caused by HPV types 16/18. 1 The estimated annual incidence of cervical dysplasia caused by HPV 16 and/or HPV 18 is approximately 195,000 persons in the United States and 233,000 persons in Europe. Cervical dysplasia can only be treated by an. Every three years from ages 30 to 65 without an HPV test. Every five years from ages 30 to 65 with an HPV test. Every year for those who have human immunodeficiency virus (HIV) or are immunocompromised. Every year for those whose mothers took a medicine called diethylstilbestrol (DES) during pregnancy acquisition due to HPV is modest. Given the burden of HPV and HIV and abundance of co-infections, HPV vaccination could prevent a non-negligible number of AIDS deaths particularly in Sub-Saharan Africa. Immunocompromised patients, particularly HIV-infected patients with CD4 cell counts <20

The risk of lung, oral, and other cancers can be reduced by quitting smoking. Because HIV-infected people have a higher risk of lung cancer, it is especially important that they do not smoke. Help with quitting smoking is available through the National Cancer Institute's (NCI's) smoking quitline at 1-877-448-7848 (1-877-44U-QUIT. Human papillomavirus (HPV) vaccine should be offered to all immunocompromised young adults with cancer (through 26 years of age) if they have not previously received the series. Meningococcal, pneumococcal, and Haemophilus influenzae type b (Hib) vaccines should be given to cancer patients with anatomical or functional asplenia, to reduce the.

In addition to treating patients, Trimble researches vaccines to treat human papillomavirus (HPV). The virus is the most common sexually transmitted infection, with more than 6 million Americans infected each year. You've probably seen television ads for the HPV vaccine. If you have kids, your pediatrician has probably recommended the vaccine. Infection of immunocompromised individuals with normally benign opportunistic viruses is a major health burden globally. Infections with viruses such as Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), Kaposi's sarcoma virus (KSHV), adenoviruses (AdV), BK virus (BKPyV), John Cunningham virus (JCPyV), and human papillomavirus (HPV) are significant concerns for the immunocompromised.

7. Use of Primary High-Risk human papillomavirus testing for cervical cancer screening. Obstet Gynecol 2015; 125(2) 330-337. HPV not done All Others Select patients HPV- HPV + Female 30 years or older HPV Positive / Pap Smear Negative HPV Genotype 16/18 Repeat Pap/HPV in 1 year Colposcopy Neg Pos PUB #681-NonDOH January 2016 Repeat cotesting at. SLE patients with a high HPV-16 viral load more frequently had SIL (n = 6) than those with a low HPV-16 viral load (n = 1; P<0.05). HPV and HPV-16 DNA positivity were not associated with previous or current drug therapy for SLE patients. All HPV-16 DNA sequences from 6 SLE and 5colposcopy patients were the European-type variant

HPV : Persistent infection with human papillomavirus (HPV) is the principal cause of cervical cancer. The presence of HPV has been implicated in more than 99% of cervical cancers worldwide, including both cervical squamous cell carcinoma and cervical adenocarcinoma. Before the development of invasive cancer, HPV infects the squamous mucosa cells and/or the glandular cells of the endocervix. Older individuals and those who are immunocompromised should continue to receive the three-dose schedule at zero, two and six months. This year, 2018, is the 12th year of human papillomavirus (HPV) vaccine delivery as part of the National Immunisation Program in Australia. Australia's 'big bang' approach, with a large-scale catch-up. Oral manifestations of HIV disease are common and include oral lesions and novel presentations of previously known opportunistic diseases. ( 1,2) Careful history taking and detailed examination of the patient's oral cavity are important parts of the physical examination, ( 3,4) and diagnosis requires appropriate investigative techniques Some people who are immunocompromised are hesitant, mostly out of fear of flare-ups and lack of long-term data. In a survey by the Leukemia & Lymphoma Society, 70% of the 6,516 patients and. HPV-Associated Cutaneous Disease Burden in HIV-Positive Patients International Journal of Dermatology . Save Recommend Share . Facebook Twitter LinkedIn Print Email.

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Immune status does not predict high-risk HPV in anal

Human papillomavirus (HPV) is a virus that causes cervical cancer and genital warts. Over time, infection with certain types of HPV can lead to cancer of the cervix, which affects more than 10,000 American women every year. HPV can also cause cancers of the vulva and vagina in women, although these cancers are much less common than cervical cancer Contains inactive human papillomavirus (HPV) proteins HPV 16 L1, and HPV 18 L1 which produce neutralizing antibodies to prevent cervical cancer, cervical adenocarcinoma, and cervical neoplasia cause by HPV. Efficacy: HPV2 has shown to be 95% to 99% effective against HPV types 16 and 18-related cervical disease in females 15 to 25 years of age Banish Outbreak in Just 1 Usage. Fast Acting! Clinically Teste

papillomavirus (HPV) in the development of premalignant and malignant skin lesions in both immunocompetent and immunocompromised patients [1]. However, in contrast to anogenital HPV-associated lesions, where the oncogenic role of mucosal α-HPV genotypes is well estab-lished, the role of HPV (especially of genus β-HPV) in The oncogenic HPV-5 and HPV-8 are the most frequent HPV types, identified in 90% of patients with EV. 1 Approximately 20 other β-HPV types are known, including HPV-9, 12, 14, 15, 17, 19 through 25, 28, 29, 36, and 47. The main histologic features of the disease are the coexistence of epidermal thickening, loose horny layer with a basket weave.

HPV and Inflammatory Arthritis: Understanding the Connectio

There is increasing evidence supporting the role of human papillomavirus (HPV) in the development of premalignant and malignant skin lesions in both immunocompetent and immunocompromised patients [].However, in contrast to anogenital HPV-associated lesions, where the oncogenic role of mucosal α-HPV genotypes is well established, the role of HPV (especially of genus β-HPV) in extragenital. Providers can help protect immunocompromised and HIV-positive patients by routinely recommending and administering HPV immunization. The materials in this toolkit will help providers start the conversation and strongly recommend HPV vaccine to their immunocompromised and HIV-positive patients. Target Audience: Healthcare providers and health. conversation about HPV vaccination with your immunocompromised and HIV-positive adult patients. HPV Vaccine is Cancer Prevention — Washington State Department of Health HPV Information for Public Health and Healthcare Providers — Washington State Department of Health Washington You are the Key to HPV Cancer Prevention — e-learning cours

The impact of quadrivalent human papillomavirus (HPV; types 6, 11, 16, and 18) L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive. The prevalence of HPV-related lesions containing both low- and high-risk HPV in patients with immunosuppression, particularly human immunodeficiency virus (HIV) infection, is higher than in the general population. 34-36 These conditions represent known predisposing factors for persistent HPV infections, with both frequent lesion persistence. Patients with poorly controlled HIV (viremia and low CD4 counts) are at higher risk for HPV-related neoplasia, with higher rates of condyloma and SIL, persistent HPV infection, extensive disease. If the immunocompromised patient is six months or older, household members may receive the inactivated influenza vaccine, or the live attenuated influenza vaccine if they are healthy, not pregnant. • Pap and HPV co testing is the preferred method • NIL with negative HPV- rescreen in 5 years • ASCUS with negative HPV- rescreen in 3 years • If unsatisfactory and negative HPV then repeat in 2-4months • Negative pap with +ve HPV, either repeat in 12 months or test for high risk HPV

9-14 years (target 11-12 year olds)3,4 15-26 years (catch up)3 27-45 years (shared decision making)5,6 GENDER Page 1 of 3 Males and females 9-valent HPV vaccine (9vHPV)7 ,8 9 Disclaimer: This algorithm has been developed for MD Anderson using a multidisciplinary approach considering circumstances particular to MD Anderson's specific patient population, services an But Immunocompromised patients like her, may have less of a response to the vaccine. According to doctors at the CDC and University Hospital, the only children who should not get the vaccine are.

Human papilloma virus-related premalignant and malignant

Background Increasing prevalence of inflammatory bowel disease (IBD) poses significant challenges to medical community. Preventive medicine, including vaccination against opportunistic infections, is important in decreasing morbidity and mortality in patients with IBD. We conduct first study to evaluate general awareness and adherence to immunisation guidelines by primary care physicians in. This collection features AFP content on child and adult immunizations (excluding influenza) and related issues, including travel immunizations and specific immunizations (hepatitis A and B, herpes.

Intravenous immunoglobulin therapy for pure red cell

Immunocompromised is a broad term which means that the immune system is weaker than expected and not functioning properly.. The immune system is made up of an army of different types of cells all. indicated for immunocompetent patients greater than 50 years old; not yet approved for use in immunocompromised patients (being studied) Shingrix vaccine: effectiveness. Successful pevention of herpes zoster (shingles) in individuals by age: 50 to 59 years old: 96.6%; 60 to 69 years old: 97.4 For white patients, a poor prognosis, including risk of death or recurrence/metastasis, is more likely to be linked with a negative high-risk HPV status, whereas for non-white patients a poor.

Aims Human papillomavirus (HPV) is considered a causative agent for the development of a broad range of human carcinomas. The role of HPV in the development of conjunctival intraepithelial neoplasia (CIN) and carcinoma (cSCC) remains unclear. The purpose of the present study was to investigate the HPV prevalence in a nationwide cohort and to describe clinical and histopathological features in. Human papillomavirus 16 was the most frequent high-risk HPV type in HIV+ MSM and occurred in 7 of 27 (26%) of high-risk HPV-positive biopsy specimens, followed by HPV 53 (5 of 27 [19%]) and HPV 31 and/or HPV 45 (4 of 27 [15%] each). Human papillomavirus 16 was only found in AGWs harboring AIN 2 or 3 or cancer

Patients should be educated that HPV infections often recur regardless of treatment method utilized, especially in the first few months. 2,3 When using self-applied treatment methods, patients should wash their hands before and after administration of any therapy to avoid further spreading of infection. Once diagnosed, patients with genital. -Immunocompromised patients may have prolonged or severe episodes; clinical manifestations of genital herpes may worsen during immune reconstitution early after initiation of antiretroviral therapy. -CDC STD Treatment Guidelines and the Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV- Exposed and HIV-Infected. Unvaccinated patients above age 26 who are at high risk of anal cancer may want to ask their care provider about getting either the quadrivalent or 9-valent HPV vaccine. Since this is an off-label use of both vaccines, it may be challenging to obtain health insurance coverage for them immunocompromised individuals ages 9-26 and individuals 27 years or older, a three-dose vaccination series is recommended.8 HPV-Associated Cancers in Illinois June 2021 States to educate patients about the HPV vaccine, and to strongly recommend HPV vaccination.1 Human papillomavirus (HPV) is a double-stranded DNA virus that occurs mostly in individuals between the ages of 15 and 25 years. 1 There are over 100 types of HPV that can affect any location in the body, from the human genital tract to the oropharyngeal tract. HPV targets the basal keratinocytes after a wound allows human cells to be exposed.

Detection of human papillomavirus DNA in skin warts from

Cancer rectal staging,

There are more than 100 strains of human papillomavirus it is not beta-HPV that encourages SCC in immunocompromised individuals. is to induce immunity that then is protecting patients from. The HPV test looks for infection by high-risk types of HPV that are more likely to cause pre-cancers and cancers of the cervix. The HPV test can be used alone (primary HPV test) or at the same time as the Pap test (called a co-test). Screening tests offer the best chance to have cervical cancer found early when treatment can be most successful Meidani M, Naeini AE, Rostami M, Sherkat R, Tayeri K. Immunocompromised patients: Review of the most common infections happened in 446 hospitalized patients. J Res Med Sci. 2014;19(Suppl 1):S71-S73. McCusker C, Upton J, Warrington R. Primary immunodeficiency. Allergy Asthma Clin Immunol. 2018;14(Suppl 2):61. Published 2018 Sep 12. doi:10.1186. Patients who are immunocompromised due to drug-induced immunosuppression or HIV infection are at particular risk of acquiring HPV and developing anogenital warts. Anogenital warts can also affect infants and young children

Human Papilloma Virus and Cancers of the Anogenital Tract and Oropharynx HPVs are commonly spread through sexual contact. These viruses are the cause of benign genital warts, and subtypes 16, 18, 31, 33, and 35 are the major subtypes that cause cervical, anal, and head and neck (primarily oropharyngeal) cancer There are two reasons for this view: (i) in immunocompromised patients (due to either human immunodeficiency viral infections or post organ transplantation therapy), there is no increased prevalence of breast cancer, which is in contrast to the twofold to sixfold increased prevalence of HPV-associated cervical cancer in these patients , and (ii.

Absence of human papillomavirus in squamous cell

  1. atum: Independent Lesions Due to Different HPV Types Occurring in Immunocompromised Patients Kruti P. Maniar , Brigitte M. Ronnett, Russell Vang, Anna Yemelyanova
  2. Including our series, we reviewed in literature 133 patients with HPV-B19 PRCA treated with IVIg. All except 2 of them were immunocompromised, including 39 HIV infected patients and 63 solid organ transplanted. After first IVIg course, hemoglobin correction was observed in 124 cases but 42 patients relapsed, in a mean time of 4,3 months
  3. Cutaneous warts, caused by human papilloma virus (HPV), often regress spontaneously or respond to common treatments, but may be refractory or recur. 1 Refractory warts, innumerable warts, or warts too large for traditional treatments occur most often in immunocompromised patients
  4. Prevention of human papillomavirus infection: Females ≥9 years of age and ≤26 years of age: Prevention of anal cancer caused by HPV types 16 and 18; anal intraepithelial neoplasia caused by HPV types 6, 11, 16, and 18 Non-immunocompromised patients and certain medical conditions: Asplenia, asthma, chronic granulomatous disease, chronic.
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Anogenital Warts - 2015 STD Treatment Guideline

  1. The human papillomavirus (HPV) is the most prevalent sexually transmitted infection (STI) in the US. HPV infection can cause genital warts, genital cancers, and oropharyngeal cancers that can lead to consequential illness or death (Hofstetter, Ompad, Stockwell, Rosenthal, & Soren, 2016). The majority of sexually active women and men will.
  2. The CDC's Advisory Committee on Immunization Practices, or ACIP, voted today on new recommendations for HPV and pneumococcal vaccination in adults. The committee voted unanimously to raise the.
  3. If you are immunocompromised because of a medical condition or medication, you are still eligible to receive the COVID-19 vaccine. The vaccine does not contain a live virus and cannot give you an infection. However, it's unclear whether people with compromised immune systems will get the same level of protection against the virus as people with functioning immune systems
  4. istered routinely to all girls and boys.
  5. However, in patients that are immunocompromised, there is an increased risk of developing vulvar, vaginal, or perianal lesions associated with HPV [8-10]. Patients with high susceptibility to local development, fast progression (growth and malignancy), and high rates of recurrence often exhibit various types of immunodeficiency [ 11 ]
  6. US Pharm. 2006;31(9):HS-8-HS-14. Human papillomavirus (HPV), the cause of genital warts, is the most common viral sexually transmitted disease in the United States. 1 Because HPV infection is not reportable to federal or local health officials and because most people with HPV do not realize they are infected, the exact prevalence and incidence are unknown
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