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Malignant cellular blue nevus

Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus In a Cellular Blue Nevus, the number of melanoma sites is much higher than a regular blue nevus, and hence it is called so. It is an unusual type of mole that in rare cases, can turn into a malignant melanoma The mole can be present anywhere on the body, though most of them are seen on the buttocks and lower back. They appear as papules or nodule A Malignant Melanoma arising from a Blue Nevus is very uncommon and is mostly observed in adults. The probability of a cellular blue nevus transforming into a malignant melanoma is greater than melanoma arising from a common blue nevus

Blue Nevus. The blue nevus is a slightly elevated, round, regular nevus, usually less than 0.5 cm, and contains large amounts of pigment located in the dermis ( Figs. 22.26 to 22.28). The brown pigment absorbs the longer wavelengths of light and scatters blue light (Tyndall effect) Cellular blue nevus (CBN) differs from classic blue nevus since it exhibits a cellular appearance and presents itself with subcutaneous infiltration, intensive pigmentation, and a large size. Thus it can be wrongly diagnosed as melanoma due to atypia criteria that may be present [ 3 - A common blue nevus is usually benign, remains unchanged throughout life, and does not lead to any complications. In rare situations, a cellular blue nevus may develop into a form of melanoma..

Definition / general Usually pigmented, biphasic tumor with component of classic blue nevus and distinct cellular areas composed of spindled to oval melanocytes with clear or finely-pigmented cytoplasm (Arch Pathol Lab Med 2011;135:327 cases, your blue nevus may be malignant. Cancerous nevi may appear as a common or cellular blue nevus but develop at a later age and may start to look like ulcers. They may also have a more nodular.. The distinction of cellular blue nevi (CBN) with atypical features [atypical CBN (ACBN)] from conventional CBN and malignant melanomas related to or derived from CBN remains a difficult problem. Here, we report on the diagnosis of various cellular blue melanocytic neoplasms by 14 dermatopathologists who routinely examine melanocytic lesions

Atypical cellular blue nevus or malignant blue nevus

A malignant blue nevus of the dorsum of the hand and a review of the literature is reported. Histopathologic examination showed the presence of a blue nevus and a cellular blue nevus, as well as a malignant blue nevus. The cellular blue nevus elements of the lesion showed the characteristic prominent neural-type fascicle Benign and malignant cellular blue nevi have been studied cytopathologically, enzymatically and electron microscopically. Scarcely pigmented, Schwann-cell-like, spindle-shaped cells which characterize cellular types of blue nevus have been found to possess tyrosinase activity and can form premelanosome systems A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes

Cellular Blue Nevus - DoveMe

Malignant blue nevus is a rare melanocytic tumor that is described by some authors as a variant of malignant melanoma, whereas others regard it as a distinct entity. To our knowledge no molecular studies of this tumor have been performed, although the molecular pathogenesis of conventional melanomas has been extensively described An amelanotic blue nevus (also known as a hypomelanotic blue nevus) is a cutaneous condition characterized by mild atypia and pleomorphism. A malignant blue nevus is a cutaneous condition characterized by a sheet-like growth pattern, mitoses, necrosis, and cellular atypia Malignant blue nevus (MBN) is a rare melanocytic lesion and controversy exists whether it is a melanoma or a unique entity. We sought to establish clinical behavior using a large national registry. All patients with MBN and melanoma from 1973 to 2008 were identified in the Surveillance Epidemiology and End Results tumor registry

WebpathologyBlue nevus - wikidoc

Melanoma arising from Blue Nevus - DoveMe

Malignant blue nevus is a rare tumor. It may arise in a blue or cellular blue nevus, a giant congenital nevus, or in a nevus of Ota, or it may be malignant from the start (765). Malignant blue nevi may involve the dermis and may be ulcerated or may present as a deep-seated expansile mass (765) Cellular blue nevus, which is a benign variant with a component of common blue nevus, as well as distinct cellular areas composed of spindled to oval melanocytes, have been described in the cervix. 241,242 Rare case reports of coexisting blue nevi and malignant melanoma have also been documented. 243,24

Video: Nevi and Malignant Melanoma Plastic Surgery Ke

The term atypical cellular blue nevus (ACBN) is used to describe borderline forms of cellular blue nevus with additional features (asymmetry, hypercellular foci, focal cytologic atypia, and occasional mitoses) that are suggestive of melanoma but not definitive . There are few case reports describing the malignant potential of these. malignant blue nevus A rare skin lesion that usually involves the scalp, presents as a multinodular plaque > 2.0 cm with a history of progressive enlargement, is often associated with a cellular blue nevus, and is histologically characterised by sheet-like growth pattern, mitoses, necrosis and marked cellular atypia Molecular and Cell Biology Network (UNESCO) MCBN: Malignant Cellular Blue Nevus (dermatology) MCBN: Mesh Common Bonding Network (gounding method used in data centers) MCBN: Myocardial Contraction Band Necrosi Patients with orbital cellular blue nevus have been found to be at risk for malignant transformation of the nevus into melanoma. 5,22 Primary orbital melanoma likely develops from congenital rests of cellular blue nevus in the orbit. 22 Tellado et al 22 found that 19 (90%) of 21 patients with orbital melanoma had blue nevus of the orbit

Benign and malignant cellular blue nevi have been studied cytopathologically, enzymatically and electron microscopically. Scarcely pigmented, Schwann-cell-like, spindle-shaped cells which characterize cellular types of blue nevus have been found to possess tyrosinase activity and can form premelanosome systems Malignant blue nevus is uncommon compared to its benign counterpart and is regarded as a rare form of malignant melanoma. We report the clinical and histological findings in eight cases. Histologically, all eight specimens showed no epidermal involvement and had contained within or were adjacent to portions of blue nevus or cellular blue nevus Malignant Cellular Blue Nevus (Melanoma Arising in Cellular Blue Nevus) David Cassarino, MD, PhD Key Facts Terminology Malignant dermal-based melanocytic neoplasm with associated cellular blue nevus or features simulating cellular blue nevus Clinical Issues Very rare tumor Usually occurs in adults Complete and wider surgical excision is necessary for local removal Originally thought to b The size of a cellular blue nevus can also get larger with time and the surface of the nevus can even ulcerate. The diagnosis can be made by visual inspection alone. Although most cases of blue nevi are benign, there is a small possibility that a cellular blue nevus can undergo malignant transformation and become a malignant cellular blue nevus. Temple-Camp CRE, Saxe N, King H: Benign and malignant cellular blue nevus. A clinicopathological study of 30 cases. Am J Dermatopathol 10:289-296, 1988 10. Boi S, Barbareschi M, Cristofolini M: Malignant cellular blue nevus with true nodal metastases. Pathologica 81:345-352, 1989 11. Connelly J, Smith JL: Malignant blue nevus

Cellular Blue Nevus Diagnosed following Excision of

  1. ance. Occasionally, larger.
  2. Blue nevi are also commonly observed as part of combined nevi, most often in conjunction with a compound or intradermal nevus, and less frequently, with a Spitz or dysplastic nevus. Cellular BN are more likely than common BN to be elevated, larger in size, and have greater malignant potential.
  3. ation showed the presence of a blue nevus and a cellular blue nevus, as well as a malignant blue nevus
  4. In particular, differentiating atypical cellular blue nevi (CBN) from melanoma (including melanoma arising in or mimicking a cellular blue nevus, the so-called malignant cellular blue nevus) can pose a significant diagnostic problem , and it has been shown that even experienced dermatopathologists often disagree in differentiating CBN.

Blue nevus: Pictures, diagnosis, removal, and mor

Malignant blue nevi (MBN) are extremely rare dermal melanocytic tumors that arise in association with atypical cellular blue nevi (ACBN), cellular blue nevi (CBN), common blue nevi (BN), or de novo. The frequency of BRAF, NRAS, and KIT mutations in malignant melanoma varies according to histological subtype and localization. These mutations are rarely observed in blue nevi, which have recently. The term blue nevus is used for a wide spectrum of melanocytic proliferations. 4 Typical blue nevi (BN) are usually confined to the dermis, and contain pigmented dendritic and fusiform melanocytes and melanophages in a usually sclerotic stroma. The proportion of the cellular components, the degree of pigmentation, the extent of stromal sclerosis, and the overall degree of cellularity may vary.

Video: Pathology Outlines - Cellular blue nevu

Blue Nevus: Identification, Removal, and Mor

cell origin. T HE MALIGNANT BLUE NEVUS (MBN) IS A RARE melanotic tumor of skin. In the small number of cases previously reported,23 678,149 151 17, 22 it closely resembles the cellular blue nevus (CBN) described by Allen and Spitz,8 and usually metastasizes to regional lymph nodes or more rarely to internal organs.8 Al Malignant blue nevus is a rare form of malignant melanoma. A cellular blue nevus is the precursor lesion. The scalp is the most common site. The tumor often presents clinically as a progressively enlarging or multinodular blue-black lesion. The histologic pattern is fascieular dense collections of pigmented, pleomorphic spindle cells

Atypical Cellular Blue Nevi (Cellular Blue Nevi With

  1. The cellular blue nevus is believed to represent a dermal arrest of embryonal migration of neural crest melanocytes that fail to reach the epidermis. They tend to remain unchanged throughout life, but there have been rare reports of malignant transformation to melanoma. CLINICAL PRESENTATION Cellular blue nevus can appear at any age but.
  2. ent nucleoli. Malignant blue nevus has been described as a distinct identity, a rare form of malignant melanoma, and a misdiagnosed melanoma. Methods: We present a patient with metastatic malignant blue nevus and studies on the histopathologic.
  3. Blue nevus is a benign melanocytic lesion whose most frequent variants are dendritic (common) blue nevus and cellular blue nevus. Atypical cellular blue nevus presents an intermediate histopathology between the typical and a rare variant of malignant blue nevus/melanoma arising in a cellular blue nevus. An 8-year-old child presented a pigmented.
  4. Cellular blue nevus. The most common subtype of blue nevus is the cellular variant, as first described by Darier. 9 Cellular blue nevi are most commonly diagnosed in adults younger than 40 years, but they can be seen at any age. Females are more frequently affected than males by a ratio of 2.2:1. 3 These lesions are usually found on the buttocks and sacrococcygeal area, and also can arise on.
  5. The term malignant blue nevus refers to a rare and heterogeneous group of melanomas that arise in several clinical settings. This includes melanomas arising in association with a common or cellular blue nevus and those arising de novo and resembling cellular blue nevi. We reviewed the clinicopathologic features of 10 cases of malignant blue nevi
  6. A cellular and malignant blue nevus: a light and electron microscopic study. Cancer 1969;24:888-896. CAS Article PubMed Google Scholar 36. Mishima Y . Cellular blue nevus..

Blue Nevus - American Osteopathic College of Dermatology

While blue nevi can usually be diagnosed upon visual inspection, in some cases it may be necessary to distinguish these moles from tumors and to rule out the rare malignant transformation of cellular blue nevi. In this context, differential diagnoses may be malignant melanoma, pigmented adenoma, carcinoma, hemangioma, histiocytoma, paraganglioma, dermatofibroma, pigmented metastases of other. The deep penetrating nevus has microscopic features that overlap ordinary blue nevus, cellular blue nevus, and spindle and epithelioid cell (Spitz) nevus [5-7].Similar to cellular blue nevus, the less-pigmented spindle and epithelioid cells toward the base of the lesion may concentrate around blood vessels and nerves producing a plexiform pattern of growth reminiscent of a neurofibroma (Fig. Reports from 267 cellular blue nevi, including 14 which had given metastases, and 12 malignant blue nevi are reviewed. Comprehensive criteria are proposed for the differential diagnosis of cellular blue nevus and malignant melanoma. The ultrastructural characteristics of the melanosomes of cellular blue nevus cells are discussed Malignant blue naevus is a distinct but rarely documented variant of malignant melanoma, and we describe the triple recurrence of a suprapatellar cellular blue naevus over 12 years in a middle-aged woman. Staging investigations revealed a distant subcutaneous metastasis of the right thigh

So‐called malignant blue nevus - Martin - 2009 - Cancer

  1. Pictures of cellular blue nevus were found in the surrounding lesions. Ten months later, new blue macular and papular lesions appeared in proximity to the surgical scar. The patient refused any additional surgery, and so was treated with dacarbazine (DTIC) 800 mg intravenously (every 20 days) and 2α interferon (3 million units subcutaneously.
  2. 15 year old girl with poliosis overlying a nevus with blue nevus features (Dermatol Online J 2008;14:20) 53 year old woman with large plaque-type blue nevus with subcutaneous cellular nodules (Am J Surg Pathol 2000;24:92) 69 year old man with blue nevus with satellitosis mimicking malignant melanoma (J Eur Acad Dermatol Venereol 2001;15:570) Blue nevus of the lymph node capsule (Pathologica.
  3. Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant blue nevus'. Granter SR, McKee PH, Calonje E, Mihm MC Jr, Busam K Am J Surg Pathol 2001 Mar;25(3):316-23. doi: 10.1097/00000478-200103000-00005
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The Blue Nevus or Malignant Melanoma? Registered Dental

  1. The term is now used in three circumstances: malignant transformation or melanoma in a preexisting blue nevus, melanoma with architectural or cytologic features resembling cellular blue nevus but apparently arising de novo, or melanoma with an admixed, residual benign cellular blue nevus component
  2. A histological diagnosis of cellular blue nevus with satellitosis was then rendered. Scalp is a classical site of cellular blue nevus that shares many features with common blue nevus 4,5 ; it is different, however, mainly because of the architecture and the prevalence of ovoid cells that show a solid pattern of growth
  3. Given both the potential for misdiagnosis and association with blue nevus-like melanoma, blue nevi require monitoring, and a biopsy performed in cases of rapid change in morphology or size. This latter point is especially true in the case of cellular blue nevi, from which malignant blue nevus most commonly arise
  4. The term malignant blue nevus refers to a rare and heterogeneous group of melanomas that arise in several clinical settings. This includes melanomas arising in association with a common or cellular blue nevus and those arising de novo and resembling cellular blue nevi. We reviewed the clinicopathologic features of 10 cases of malignant blue nevi. Six cases proved to be de novo melanoma.
  5. Malignant blue nevus is a heterogeneous group of melanomas that are highly aggressive and often lethal, with a propensity for metastasis to the lymph nodes and lungs. PAUCI-MELANOTIC CELLULAR BLUE NEVUS : Congenital pauci-melanotic cellular blue nevus. Busam KJ, Lohmann CM

Blue naevus DermNet N

How is Malignant Cellular Blue Nevus (dermatology) abbreviated? MCBN stands for Malignant Cellular Blue Nevus (dermatology). MCBN is defined as Malignant Cellular Blue Nevus (dermatology) very rarely Synonym (s) Nevus bleu maligner. Definition. This section has been translated automatically. Malignant transformation of a blue nevus, usually starting from the cellular type of the blue nevus, with rapid lymphogenic metastasis. Histology. This section has been translated automatically

Nevus, Blue; Blue Nevus; Cellular Blue Nevus

nevus of Ota (Ota's nevus) a persistent mongolian spot-like lesion, usually present at birth and unilateral, involving the conjunctiva and skin about the eye, as well as the sclera, ocular muscles, retrobulbar fat, periosteum, and buccal mucosa.It is a blue or gray-brown patchy area of pigmentation that grows slowly and becomes deeper in color. Although the lesion is benign, malignant. Blue nevus is a type of melanocytic nevus which clinically presents itself as blue/gray plaque or nodule. It most commonly develops upon distal extremities especially dorsal hands and feet, trunk and scalp. Histopathologically, heavy melanocyte aggregations in the deep dermis result in blue nevus formation. Different types of blue nevus include common blue nevus, cellular blue nevus, plaque. The blue nevus is composed of pigmented dermal melanocytes and is represented by two histolog-ic types: the common blue nevus and the cellular blue nevus. These two variants can sometimes be differentiated on clinical appearance. LAMB syndrome is the association of blue nevi with lentigines and skin papules and underlying atrial cardiac myxomas

Blue Nevus. Anubha Bajaj* Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper. READ PAPER TY - JOUR T1 - Congenital pauci-melanotic cellular blue nevus. AU - Busam,Klaus J, AU - Lohmann,Christina M, PY - 2004/3/10/pubmed PY - 2004/10/22/medline PY - 2004/3/10/entrez SP - 312 EP - 7 JF - Journal of cutaneous pathology JO - J Cutan Pathol VL - 31 IS - 4 N2 - Unusual or atypical melanocytic nevi can be confused with malignant melanoma A malignant blue nevus might develop in a common blue or cellular blue nevus, a giant congenital nevus or in a nevus of Ota, or it may be malignant from the start. Malignant blue nevi most commonly are found on the scalp. A malignant blue nevus of the lip has not been previously reported in the medical literature Malignant blue nevus is a rare form of malignant melanoma. It may arise in a blue nevus, nevus of Ota or may be malignant from start. Those arising in a blue nevus occur only in cellular type. The most common site for its occurrence is scalp, even though blue nevi most commonly occur on the dorsum of the hands and feet

The cellular blue nevus is believed to represent a dermal arrest of embryonal migration of neural crest melanocytes that fail to reach the epidermis. They tend to remain unchanged throughout life, but there have been rare reports of malignant transformation to melanoma ence of an associated cellular blue nevus on pathologic examination of an orbital melanoma provides evidence supporting a primary orbital melanoma because the cel-lular blue nevus component is a precursor lesion. 4,5 We report 3 cases of primary orbital melanoma associated with a cellular blue nevus. Subjects and Method In addition, the term malignant blue nevus has been applied most often to melanomas that arise in the background of cellular blue nevus [15-17]. In the literature there are some reported cases of melanoma that arose in a congenital CBN in older patients (73 and 69 years) with a predilection for the scalp area [ 18 , 19 ] Blue nevus also known as blue neuronevus, dermal melanocytoma, and nevus bleu is a type of melanocytic nevus.The blue colour is caused by the melanin pigment being deeper in the skin than in ordinary nevi. Blue nevus commonly arise in adulthood but in some cases they are present at birth or during the first year of life

Blue nevus (Common, Dendritic, Cellular Blue Nevus

  1. Ovoid, clear cells are abundant Clear cells show small, round to oval monomorphous nuclei; eosinophilic or clear cytoplasm Heavily pigmented spindled and dendritic cells alternate with clear cells Top Differential Diagnoses • Atypical cellular blue nevus • Melanoma arising in or mimicking cellular blue nevus (malignant blue nevus) • Desmoplastic melanoma Diagnostic Checklist • Clinical.
  2. The clinical and pathological features of 29 cellular blue nevi (CBN) and one malignant cellular blue nevus from our hospital files were reviewed. Although the sacrococcygeal region/buttock was the commonest single site, the majority of CBN occurred on the limb peripheries. Two-thirds of patients were under the age of 40 years
  3. Cellular blue nevus seen on dorsa of hands, feet, buttock or face [1, 2]. Progressive growth is rare and rarely malignant transformation can occur in cellular blue nevus
  4. Key histologic features helpful in differentiating between cellular blue nevus, atypical cellular blue nevus, malignant blue nevus, and PEM are summarized in the Table. Amelanotic cellular blue nevus: a hypopigmented variant of the cellular blue nevus: clinicopatho logic analysis of 20 cases
  5. surgical treatment. Reports from 267 cellular blue nevi, including 14 which had given metastases, and 12 malignant blue nevi are reviewed. Compre- hensive criteria are proposed for the differential diagnosis of cellular blue nevus and malignant melanoma. The ultrastructural characteristics of th

DD Nodular melanoma Metastatic melanoma Giant cellular blue nevus with subcutaneous cellular nodules 8. Ki-67 9. Bimodal age presentation Most commonly on trunk Presents as a firm nodule or dark brown to black discoloured area in the midst of the naevus Can also present as a cyst 10 Granter SR, McKee PH, Calonje E, et al. Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant blue nevus'. Am J Surg Pathol 2001; 25:316. Aloi F, Pich A, Pippione M. Malignant cellular blue nevus: a clinicopathological study of 6 cases The common blue nevus is a solitary, bluish, smooth surfaced macule, papule or plaque. They are generally round or oval in shape. The common blue nevus is usually 0.5-1 cm in diameter. The cellular blue nevus is more nodular and is at least 1 cm in diameter An atypical cellular blue nevus, a benign mass, may sometimes transform into a malignant melanoma. Here, we report a rare case of melanoma arising in a large congenital vulvar blue nevus. A 28‐year‐old Chinese woman presented to our hospital with a chief complaint of a vulvar mass that had persisted for 8 years

Blue Nevus - Cell Carcinoma - Derick Mussen HealthcareBlue naevus | DermNet NZIntro to Derm - Physician Assistant Studies 7110 with

Once a blue nevus appears, it tends to remain unchanged throughout life. Occasionally, common blue nevi flatten and fade in color. These changes are evenly distributed throughout the lesion. Malignant change in cellular blue nevi may be heralded by a sudden increase in size and occasionally ulceration The histologic appearance of the tumors may be that of a malignant or cellular blue nevus (CBN) . In a few instances, a primary melanoma of the choroid, iris, orbit, or brain has developed in patients with a nevus of Ota involving an eye (23,24). Copy number variations studied by comparative genomic hybridization have been described in one such. Histologically, the primary tumor and the metastases fulfill the criteria for the diagnosis of malignant cellular blue nevus. Electron microsopic studies of the tumor metastases do not support the few recently reported observations of the ultrastructural resemblance of the tumor cells of malignant blue nevus with Schwann cells Atypical cellular blue nevi (cellular blue nevi with atypical features): Lack of consensus for diagnosis and distinction from cellular blue nevi and malignant melanoma (malignant blue nevus). American Journal of Surgical Pathology , 32 (1), 36-44 Subsequently, a few nevus (Fig 3C). The diagnosis of malignant blue nevus was pigmented nodules become apparent in the periauricular supported by the presence of cellular blue nevus in the vicin- skin. At the age of 11 years, a soft, fluctuant, painless, rapidly ity of the malignant blue nevus The blue nevus is found most frequently on the skin; however, in rare instances, it has been reported on oral mucous membranes. Intramucosal nevi make up more than one half of all reported intraoral melanocytic nevi. The common blue nevus is the second most common variant. Among the 3 variants of blue nevi, the cellular variant occurs less frequently than the common and combined variants